Pre-clinical studies

Exploratory pre-clinical studies generate new hypotheses, typically in animal models of disease; confirmatory pre-clinical studies confirm (or reject) these hypothesis and convert them into reproducible knowledge that can then be the basis for further clinical research and development.

Our vision and mission

Pre-clinicalTrials.org provides unprecedented tools to enhance the validity of pre-clinical research, its reproducibility and later success rate with respect to clinical translation.

We do so by enabling meta-analyses through providing access to hitherto unpublished and inaccessible data and combining them, if desired, with Big Data of different evidence levels.


2016: Pre-ClinicalTrials.org Consortium formed, website initiated


  • Kleinschnitz et al. NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage. Journal of Cerebral Blood Flow & Metabolism. SAGE Publications; 2016 Jun 28;:0271678X16657094.
  • Kleikers et al. A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation. Sci Rep. 2014 Dec 31;5:13428–8.
  • Llovera & Liesz. The next step in translational research: lessons learned from the first preclinical randomized controlled trial. J Neurochem. 2016 Mar 10
  • Llovera et al. Results of a preclinical randomized controlled multicentre trial (pRCT): Anti-CD49d treatment for acute brain ischemia. Sci Transl Med. American Association for the Advancement of Science; 2015 Aug 5;7(299):299ra121–1.


Membership is regulated in a Memorandum of Understanding (latest version from October 2016). Further regulations are detailed in the Terms & Conditions section.