The latest version of LINEX has been published in Briefings in Bioinformatics.
Please check out this much revised version of the previously published preprint, which not only improved the manuscript but also crucial features of the LINEX web service:
Rose and Köhler et al. Lipid network and moiety analysis for revealing enzymatic dysregulation and mechanistic alterations from lipidomics data. Briefings in Bioinformatics 2023, bbac572
After great feedback from users on the LINEX2 web service version 2.3 is now online. The update includes the following changes:
We are happy to present an updated version of LINEX2 manuscript. Check it out here: Rose and Köhler et al. Lipid network and moiety analysis for revealing enzymatic dysregulation and mechanistic alterations from lipidomics data. bioRxiv 2022, 2022.02.04.479101
Thanks to user feedback we found bugs for LINEX1, that occurred during the transition to version 2. The errors are resolved and LINEX1 analyses should run smoothly again.
We updated the tutorial to guide you through all the new features of LINEX. Check it out here: Tutorial.
Our preprint about all the new features of LINEX version 2 is online.
We explain the motivation and functionality of our network enrichment and moiety/substructure analysis.
Please read the manuscript before using LINEX 2.0:
Rose and Köhler et al. Lipid network and moiety analyses reveal enzymatic dysregulation and altered mechanisms from lipidomics. bioRxiv 2022, 2022.02.04.479101
We are happy to announce the launch of LINEX Version 2.0.
This new version is build on reactions from the Rhea and Reactome databases, thus simplifying many settings,
and with a dedicated network enrichment algorithm to find hypotheses for mechanistic changes of enzymatic activity.
The paper will be available soon.
We fixed a bug leading to nodes to be invisble in the standalone html when certain node size properties are selected.
Material from our ILS Conference workshop is available here.
Based on user feedback we added additional options for statistical tests. You can now choose between (parametric) t-test, non-parametric unpaired tests and non-parametric paired tests.
Checkout our new tutorial on youtube or on top of the page on using LINEX to get started with your analysis.
We updated the LINEX layout to make working with LINEX even easier and more structured. Analyze your Lipidomics data now!
We will make a workshop about LINEX and our sample stratification tool MoSBi at the International Lipidomics Society annual conference on October 5th - 8th, 2021 in Regensburg, Germany. Get hands-on experience with LINEX and learn about new ways to analyze lipidomics data.
More details about the workshop here: ILS 2021 workshops
Register for the conference here: ILS 2021 Registration
We are happy to anounce that LINEX is published in Metabolites. Check out the publication here: Köhler and Rose et al. Investigating Global Lipidome Alterations with the Lipid Network Explorer
The Lipid Network Explorer web application is online! Our tool to provide a global view on the lipidome with lipid metabolic networks is now available to everyone. We hope to present the official publication to you soon. If you have any questions of feedback for us, please contact us!